Simultaneous multi‐slice spin‐ and gradient‐echo dynamic susceptibility‐contrast perfusion‐weighted MRI of gliomas. (25th August 2020)

• Record Type: Journal Article
• Authors: Han, Misung; Yang, Baolian; Fernandez, Brice; Lafontaine, Marisa; Alcaide‐Leon, Paula; Jakary, Angela; Burns, Brian L.; Morrison, Melanie A.; Villanueva‐Meyer, Javier E.; Chang, Susan M.; Banerjee, Suchandrima; Lupo, Janine M.
• Is Part Of: NMR in biomedicine. Volume 34:Number 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-25
• Subjects: dynamic susceptibility‐contrast imaging -- gliomas -- perfusion -- simultaneous multi‐slice acceleration -- spin‐echo and gradient‐echo EPI; Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.4399
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract : Although combined spin‐ and gradient‐echo (SAGE) dynamic susceptibility‐contrast (DSC) MRI can provide perfusion quantification that is sensitive to both macrovessels and microvessels while correcting for T 1 ‐shortening effects, spatial coverage is often limited in order to maintain a high temporal resolution for DSC quantification. In this work, we combined a SAGE echo‐planar imaging (EPI) sequence with simultaneous multi‐slice (SMS) excitation and blipped controlled aliasing in parallel imaging (blipped CAIPI) at 3 T to achieve both high temporal resolution and whole brain coverage. Two protocols using this sequence with multi‐band (MB) acceleration factors of 2 and 3 were evaluated in 20 patients with treated gliomas to determine the optimal scan parameters for clinical use. Δ R 2 *( t ) and Δ R 2 ( t ) curves were derived to calculate dynamic signal‐to‐noise ratio (dSNR), Δ R 2 *‐ and Δ R 2 ‐based relative cerebral blood volume (rCBV), and mean vessel diameter (mVD) for each voxel. The resulting SAGE DSC images acquired using MB acceleration of 3 versus 2 appeared visually similar in terms of image distortion and contrast. The difference in the mean dSNR from normal‐appearing white matter (NAWM) and that in the mean dSNR between NAWM and normal‐appearing gray matter were not statistically significant between the two protocols. Δ R 2 *‐ and Δ R 2 ‐rCBV maps and mVD maps provided unique contrast and spatial heterogeneity within tumors. Abstract : Spin‐ and gradient‐echo (SAGE) DSC MRI allows us to quantify perfusion parameters sensitive to both macrovessels and microvessels. This work combined SAGE EPI with simultaneous multislice (SMS) excitation and blipped CAIPI to provide high temporal resolution and large spatial coverage. We demonstrate that applying an SMS acceleration factor of 3 provided image quality, dynamic SNR in transverse relaxation‐rate change curves, and perfusion parameters, similar to applying an SMS acceleration factor of 2 for patients with gliomas, qualitatively or quantitively.