Genome‐wide association analysis of psoriasis patients treated with anti‐TNF drugs. Issue 12 (29th October 2020)

• Record Type: Journal Article
• Authors: Ovejero‐Benito, María C.; Muñoz‐Aceituno, Ester; Sabador, David; Almoguera, Berta; Prieto‐Pérez, Rocío; Hakonarson, Hakon; Coto‐Segura, Pablo; Carretero, Gregorio; Reolid, Alejandra; Llamas‐Velasco, Mar; Abad‐Santos, Francisco; Daudén, Esteban
• Is Part Of: Experimental dermatology. Volume 29:Issue 12(2020)
• Page Start: 1225
• Page End: 1232
• Publication Date: 2020-10-29
• Subjects: biological drugs -- biomarkers -- microarray -- pharmacogenetics -- pharmacogenomics -- psoriasis; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.14215
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: While anti‐TNF therapies are effective against psoriasis, 30%–50% of patients do not show an adequate response to these drugs. Different candidate‐gene pharmacogenetics studies have identified single nucleotide polymorphisms that may predict anti‐TNF drugs response in psoriasis. Nevertheless, only one paper has undertaken a pharmacogenomic approach failing to find significant biomarkers of biological drug response along the whole genome. Furthermore, most of the pharmacogenetic candidate biomarkers identified previously have not been confirmed in a different cohort of patients. The objective of this study was to find biomarkers that could predict anti‐TNF drugs response along the whole genome and validate biomarkers identified previously. A genome‐wide association study (GWAS) was performed using the Human Omni Express‐8 v1.2 Beadchips in 243 psoriasis patients treated with anti‐TNF drugs. This study was multicentric and did not interfere with clinical practice. Associations between single nucleotide polymorphisms (SNP) and PASI75 (a 75% reduction with respect to baseline PASI) at 3 months were evaluated. Imputation was performed using SNPs with R 2 > 0.7. There were two SNPs located in NPFFR2 that were close to the significant threshold of 5 × 10 −8 . These data suggest that NPFFR2 might be associated with anti‐TNF drug response. However, further studies involving a larger cohort of patients are needed in order to confirm these results.