Dielectrophoretic Manipulation of Janus Particle in Conductive Media for Biomedical Applications. Issue 12 (1st November 2020)

• Record Type: Journal Article
• Authors: Lee, Minji; Won, Jong Bin; Jung, Dae Ho; Kim, Jaekyoung; Choi, Yonghyun; Akyildiz, Kubra; Choi, Jonghoon; Kim, Kyobum; Cho, Jiung; Yoon, Hyunsik; Koo, Hyung‐Jun
• Is Part Of: Biotechnology journal. Volume 15:Issue 12(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-11-01
• Subjects: AC frequency -- dielectrophoresis -- electrothermal effect -- Janus particles -- medium conductivity; Biotechnology -- Periodicals; 660.605
• DOI: 10.1002/biot.202000343
• Languages: English
• ISSNs: 1860-6768

Abstract

Abstract: Janus particles are applied to many fields including biomedical applications. To expand the usability of Janus particles, a technique to manipulate the particle movement is required. A dielectrophoresis (DEP) method can be a promising candidate; however, independent manipulation or separation of Janus particle by DEP is still challenging. Additionally, DEP of Janus particles in conductive media is important especially for biomedical applications where ion‐rich media are typically used. Here, the experimental results of DEP‐induced transport and separation of the Janus particle in conductive media are presented. To predict the DEP behavior, the Clausius–Mossotti (CM) factors of both Janus and homogeneous particles are calculated, depending on the alternating current (AC) frequency and medium conductivity. The Janus particles show the positive‐DEP behavior at the entire AC frequency region tested due to the metal‐coated half surface. On the other hand, the homogeneous particles show the negative‐DEP behavior at the high AC frequency or in conductive media. Additionally, in the conductive media, an electrohydrodynamic flow hinders the DEP‐driven particle transport below MHz AC frequencies. Finally, the separation of the Janus particles from the homogeneous ones is experimentally demonstrated and the separation efficiency is discussed based on the evaluation parameters established in this study. Abstract : Janus particles with two surfaces with different physicochemical properties are applied to various fields, including biomedical applications. In this study, the dielectrophoretic behavior of the Janus particle in conductive media is investigated. Furthermore, the separation of the Janus particle from the homogeneous one by dielectrophoresis is experimentally demonstrated. This article is part of an AFOB (Asian Federation of Biotechnology) Special issue. To learn more about the AFOB visit www.afob.org .