Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective. Issue 4 (23rd September 2020)

• Record Type: Journal Article
• Authors: Lien, Brian V.; Brown, Nolan J.; Ransom, Seth C.; Lehrich, Brandon M.; Shahrestani, Shane; Tafreshi, Ali R.; Ransom, Ryan C.; Sahyouni, Ronald
• Is Part Of: Journal of the peripheral nervous system. Volume 25:Issue 4(2020)
• Page Start: 320
• Page End: 334
• Publication Date: 2020-09-23
• Subjects: bioengineered scaffolds -- neural scaffolds -- neurotrophic factors -- peripheral nerve injury -- peripheral nerve regeneration -- peripheral nerve repair; Nervous system -- Periodicals; Nerves, Peripheral -- Diseases -- Periodicals; Peripheral Nervous System Diseases -- Periodicals; Peripheral Nervous System -- Periodicals; 612.81
• DOI: 10.1111/jns.12414
• Languages: English
• ISSNs: 1085-9489

Abstract

Abstract: Despite the peripheral nervous systems (PNS) capacity to regenerate, functional restoration is highly variable following peripheral nerve injury (PNI), oftentimes leading to persistent functional deficits. In the preclinical arena, advances in the therapeutic use of exogenous neurotrophic factors and synthetic neural scaffold technology hold promise in augmenting endogenous PNS regeneration following PNI. Clinical trials utilizing neurotrophic factors for other indications (eg, peripheral neuropathy) may provide insight into their role in PNI. Here we provide an updated review of progress made toward enhancing regeneration after PNI with a focus on neurotrophic factors and bioengineered scaffolds.