Fungal factors involved in host immune evasion, modulation and exploitation during infection. (13th October 2020)

• Record Type: Journal Article
• Authors: König, Annika; Müller, Rita; Mogavero, Selene; Hube, Bernhard
• Is Part Of: Cellular microbiology. Volume 23:Number 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-13
• Subjects: effector proteins -- fungal virulence factors -- host exploitation -- host modulation -- human pathogenic fungi -- immune evasion -- plant pathogenic fungi; Microbiology -- Periodicals; Cytology -- Periodicals; Host-parasite relationships -- Periodicals; Microbiology -- Periodicals; Cells -- Periodicals; Microbiologie -- Périodiques; Microbiologie; Relation hôte-parasite; Cytologie; Cellule; Réponse cellulaire; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 579.05
• DOI: 10.1111/cmi.13272
• Languages: English
• ISSNs: 1462-5814

Abstract

Abstract: Human and plant pathogenic fungi have a major impact on public health and agriculture. Although these fungi infect very diverse hosts and are often highly adapted to specific host niches, they share surprisingly similar mechanisms that mediate immune evasion, modulation of distinct host targets and exploitation of host nutrients, highlighting that successful strategies have evolved independently among diverse fungal pathogens. These attributes are facilitated by an arsenal of fungal factors. However, not a single molecule, but rather the combined effects of several factors enable these pathogens to establish infection. In this review, we discuss the principles of human and plant fungal pathogenicity mechanisms and discuss recent discoveries made in this field.