Catalyst Free, Multicomponent Green Approach to Benzo[a]chromeno[2, 3‐c]phenazines Using Glycerol as a Recyclable and Biodegradable Promoting Medium. Issue 45 (2nd December 2020)

• Record Type: Journal Article
• Authors: Nazeef, Mohd; Saquib, Mohammad; Tiwari, Saurabh Kumar; Yadav, Vikas; Ansari, Saif; Sagir, Hozeyfa; Hussain, Mohd. Kamil; Siddiqui, I. R.
• Is Part Of: ChemistrySelect. Volume 5:Issue 45(2020)
• Page Start: 14447
• Page End: 14454
• Publication Date: 2020-12-02
• Subjects: Benzo[a]chromeno[2, 3-c]phenazines -- Bio-renewable -- Glycerol -- Green chemistry -- Multicomponent reactions; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202003732
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A series of benzo[ a ]chromeno[2, 3‐ c ]phenazine derivatives were synthesized through an efficient one‐pot, multicomponent eco‐friendly reaction of 2‐hydroxynaphthalene‐1, 4‐dione, o ‐phenylenediamines, cyclic 1, 3‐dicarbonyl compounds and aromatic aldehydes, promoted by glycerol. To the best of our knowledge this is the first catalyst free protocol for synthesis of this important scaffold having potential applications in medicinal and materials chemistry. Other important attributes of the present method are the use of glycerol as a bio‐renewable and biodegradable reaction medium‐cum‐promoter, use of readily available substrates, mild reaction conditions, operational simplicity, broad substrate scope, short reaction time, easy workup, and high yields and atom efficiency, which makes the disclosed protocol a superior alternative to existing methods. Abstract : A series of twenty‐one benzo[ a ]chromeno[2, 3‐ c ]phenazines, which are important scaffolds with immense applications in medicinal and materials chemistry, were synthesized through an efficient and green, catalyst‐free, one‐pot multicomponent strategy. The key features of the present method are the use of glycerol as a bio‐renewable and biodegradable reaction medium‐cum‐promoter, use of readily available substrates, mild reaction conditions, broad substrate scope, operational simplicity, short reaction time, easy workup and high yields, which makes the disclosed protocol a superior alternative to existing methods.