Associations of coenzyme Q10 with endothelial function in hemodialysis patients. Issue 1 (1st September 2020)

• Record Type: Journal Article
• Authors: Gao, Jian‐jun; Xu, Yong‐xing; Jia, Hua‐ping; Zhang, Li; Cao, Xue‐ying; Zuo, Xiao‐wen; Cai, Guang‐yan; Chen, Xiang‐mei
• Is Part Of: Nephrology. Volume 26:Issue 1(2021)
• Page Start: 54
• Page End: 61
• Publication Date: 2020-09-01
• Subjects: coenzyme Q10 -- endothelial dysfunction -- hemodialysis; Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrologists -- Periodicals; 616.61; 616.61
• DOI: 10.1111/nep.13766
• Languages: English
• ISSNs: 1320-5358

Abstract

Abstract: Background: Endothelial dysfunction is common in patients undergoing hemodialysis (HD). However, little is known about the relationship between endothelial dysfunction and coenzyme Q10 (CoQ10) levels in HD patients. Methods: Eligible HD patients were enrolled in this study according to prespecified inclusion and exclusion criteria. Endothelial function was assessed by brachial artery flow‐mediated dilation (FMD). Plasma CoQ10, serum malondialdehyde (MDA) and 8‐hydroxydeoxyguanosine (8‐OHdG) levels were measured. The potential confounders identified by univariate analyses ( P < 0.15) were selected in a stepwise multiple regression model. Results: In total, 111 HD patients were enrolled in this study. The mean CoQ10 level was 633.53 ± 168.66 ng/mL, and endothelial dysfunction was prevalent (91.0%) using a cut‐off value of 10% FMD. A significant correlation was observed between FMD and plasma CoQ10 level ( r = 0.727, P < 0.001). After adjusting for potential parameters, a stepwise multivariate linear regression analysis revealed that CoQ10 level was an independent predictor of FMD ( β = 0.018, P < 0.001). When CoQ10 was dichotomized using the median value (639.74 ng/mL), the conclusion remained unchanged ( β = 0.584, P < 0.001). Pearson's correlation analyses revealed that plasma CoQ10 level was negatively correlated with MDA ( r = −0.48, P < 0.001) and 8‐OHdG (r = −0.43, P < 0.001) levels. Conclusion: Our data demonstrate that impaired brachial artery FMD was common in HD patients. CoQ10 level was independently associated with FMD, and oxidative stress may constitute a link between CoQ10 level and endothelial dysfunction in these patients. SUMMARY AT A GLANCE: The present study investigated the association between endothelial dysfunction and CoQ10 levels in HD patients. Impaired brachial artery flow‐mediated dilatation (FMD) was common, and CoQ10 level was independently associated with FMD. Oxidative stress may constitute a link between them.