The APOE ε4 exerts differential effects on familial and other subtypes of Alzheimer's disease. Issue 12 (3rd September 2020)

• Record Type: Journal Article
• Authors: Jia, Longfei; Xu, Hui; Chen, Shuoqi; Wang, Xiu; Yang, Jianwei; Gong, Min; Wei, Cuibai; Tang, Yi; Qu, Qiumin; Chu, Lan; Shen, Lu; Zhou, Chunkui; Wang, Qi; Zhao, Tan; Zhou, Aihong; Li, Ying; Li, Fangyu; Li, Yan; Jin, Hongmei; Qin, Qi; Jiao, Haishan; Li, Yan; Zhang, Heng; Lyu, Diyang; Shi, Yuqing; Song, Yang; Jia, Jianping
• Is Part Of: Alzheimer's & dementia. Volume 16:Issue 12(2020)
• Page Start: 1613
• Page End: 1623
• Publication Date: 2020-09-03
• Subjects: Alzheimer's disease -- APOE -- dementia -- gene mutation -- genetic risk effect -- prevalence; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12153
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: The genetic risk effects of apolipoprotein E ( APOE ) on familial Alzheimer's disease (FAD) with or without gene mutations, sporadic AD (SAD), and normal controls (NC) remain unclear in the Chinese population. Methods: In total, 15 119 subjects, including 311 FAD patients without PSEN1, PSEN2, APP, TREM2, and SORL1 pathogenic mutations (FAD [unknown]); 126 FAD patients with PSENs / APP mutations (FAD [ PSENs/APP ]); 7234 SAD patients; and 7448 NC were enrolled. The risk effects of APOE ε4 were analyzed across groups. Results: The prevalence of the APOE ε4 genotype in FAD (unknown), FAD ( PSENs/APP ), SAD, and NC groups was 56.27%, 26.19%, 36.23%, and 19.54%, respectively. Further, the APOE ε4 positive genotype had predictive power for FAD (unknown) risk (odds ratio: 4.51, 95% confidence interval: 3.57–5.45, P < .001). Discussion: APOE ε4 positive genotype may cause familial aggregation, and the investigation of multiple interventions targeting APOE pathological function to reduce the risk for this disease warrants attention.