Revisiting 3D chromatin architecture in cancer development and progression. Issue 19 (17th September 2020)

• Record Type: Journal Article
• Authors: Feng, Yuliang; Pauklin, Siim
• Is Part Of: Nucleic acids research. Volume 48:Issue 19(2020)
• Page Start: 10632
• Page End: 10647
• Publication Date: 2020-09-17
• Subjects: Nucleic acids -- Periodicals; Molecular biology -- Periodicals; 572.805
• DOI: 10.1093/nar/gkaa747
• Languages: English
• ISSNs: 0305-1048

Abstract

Abstract: Cancer development and progression are demarcated by transcriptional dysregulation, which is largely attributed to aberrant chromatin architecture. Recent transformative technologies have enabled researchers to examine the genome organization at an unprecedented dimension and precision. In particular, increasing evidence supports the essential roles of 3D chromatin architecture in transcriptional homeostasis and proposes its alterations as prominent causes of human cancer. In this article, we will discuss the recent findings on enhancers, enhancer–promoter interaction, chromatin topology, phase separation and explore their potential mechanisms in shaping transcriptional dysregulation in cancer progression. In addition, we will propose our views on how to employ state-of-the-art technologies to decode the unanswered questions in this field. Overall, this article motivates the study of 3D chromatin architecture in cancer, which allows for a better understanding of its pathogenesis and develop novel approaches for diagnosis and treatment of cancer.