Epidemiology of Seasonal Coronaviruses: Establishing the Context for the Emergence of Coronavirus Disease 2019. (14th April 2020)

• Record Type: Journal Article
• Authors: Nickbakhsh, Sema; Ho, Antonia; Marques, Diogo F P; McMenamin, Jim; Gunson, Rory N; Murcia, Pablo R
• Is Part Of: Journal of infectious diseases. Volume 222:Number 1(2020)
• Page Start: 17
• Page End: 25
• Publication Date: 2020-04-14
• Subjects: SARS-CoV-2 -- Acute respiratory infections -- Disease surveillance -- Coinfection -- Virus-virus interactions; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa185
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Public health preparedness for coronavirus (CoV) disease 2019 (COVID-19) is challenging in the absence of setting-specific epidemiological data. Here we describe the epidemiology of seasonal CoVs (sCoVs) and other cocirculating viruses in the West of Scotland, United Kingdom. We analyzed routine diagnostic data for >70 000 episodes of respiratory illness tested molecularly for multiple respiratory viruses between 2005 and 2017. Statistical associations with patient age and sex differed between CoV-229E, CoV-OC43, and CoV-NL63. Furthermore, the timing and magnitude of sCoV outbreaks did not occur concurrently, and coinfections were not reported. With respect to other cocirculating respiratory viruses, we found evidence of positive, rather than negative, interactions with sCoVs. These findings highlight the importance of considering cocirculating viruses in the differential diagnosis of COVID-19. Further work is needed to establish the occurrence/degree of cross-protective immunity conferred across sCoVs and with COVID-19, as well as the role of viral coinfection in COVID-19 disease severity. Abstract : Our study provides a comprehensive evaluation of in whom, and when, seasonal coronavirus infections occur. We compare infection patterns across coronavirus types, evaluate evidence of interactions with other respiratory viruses, and discuss implications for newly emerged coronavirus disease 2019.