Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing. (7th May 2020)

• Record Type: Journal Article
• Authors: Biswas, Chayanika; Wang, Qinning; van Hal, Sebastiaan J; Eyre, David W; Hudson, Bernard; Halliday, Catriona L; Mazsewska, Krystyna; Kizny Gordon, Alice; Lee, Andie; Irinyi, Laszlo; Heath, Christopher H; Chakrabarti, Arunaloke; Govender, Nelesh P; Meyer, Wieland; Sintchenko, Vitali; Chen, Sharon C-A
• Is Part Of: Open forum infectious diseases. Volume 7:Number 5(2020)
• Publication Date: 2020-05-07
• Subjects: Candida auris -- drug resistance -- whole-genome sequencing; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa158
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.