Piezoelectric and photothermal dual functional film for enhanced dermal wound regeneration via upregulation of Hsp90 and HIF-1α. (September 2020)

• Record Type: Journal Article
• Authors: Chen, Yanxin; Ye, Mengqi; Song, Liwan; Zhang, Junwen; Yang, Yao; Luo, Sha; Lin, Minjie; Zhang, Qianwen; Li, Shengyu; Zhou, Yajiao; Chen, Anqi; An, Ying; Huang, Wen; Xuan, Tengxiao; Gu, Yugui; He, Huacheng; Wu, Jiang; Li, Xiaokun
• Is Part Of: Applied materials today. Volume 20(2020)
• Publication Date: 2020-09
• Subjects: Piezoelectric -- Photothermal -- Wound healing -- Polydopamine -- Chitosan; Materials science -- Periodicals; Materials -- Research -- Periodicals; 620.1105
• DOI: 10.1016/j.apmt.2020.100756
• Languages: English
• ISSNs: 2352-9407

Abstract

Highlights: A piezoelectric and photothermal dual functional film is simply fabricated. The film enhances dermal wound healing by electric stimulation and NIR induced photothermal effect. The film accelerates wound healing by promoting cell proliferation, angiogenesis, and re-epithelialization. The film improves wound healing by upregulation of Hsp90 and HIF-1α. Abstract: Skin wounds, especially chronic wounds such as pressure and diabetic ulcers, are posing a huge threat to healthcare systems worldwide. Thus, novel strategies to realize effective wound therapy are nowadays extremely needed. Herein, we are the first to report a combination therapy of electric stimulation and heat for wound healing just using a facile piezoelectric and photothermal dual functional film. The film, name as CM@DA, is simply fabricated by coating polydopamine on a chitosan film. CM@DA generates electric voltages under mechanical pressure and shows photothermal effect with irradiation of near-infra red (NIR) light. In vivo experiment with rat full-thickness wound model validates that CM@DA with NIR can effectively promote wound regeneration due to the generation of electric stimulation and heat on wounds. The healing mechanism of CM@DA is further investigated, and the result demonstrates that CM@DA enhances wound healing through a pathway in which heat shock protein 90 (Hsp90) and hypoxia-inducible factor 1α (HIF-1α) participate. These results indicate that CM@DA is a promising wound dressing candidate for clinical application in the future. Graphical abstract: Image, graphical abstract