Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus. (1st November 2018)

• Record Type: Journal Article
• Authors: Manzke, Pedro; Grippe, Talyta; Tavares, Georgia L.; Leal, Lucas C.; Roze, Emmanuel; Apartis, Emmanuelle; Maciel Dias, Ronaldo; Ferreira, André G. F.
• Editors: Louis, Elan D.
• Is Part Of: Tremor and other hyperkinetic movements. Volume 8(2018)
• Publication Date: 2018-11-01
• Subjects: Anti-glutamic acid decarboxylase antibodies -- stiff person syndrome -- autoimmunity -- myoclonus -- epilepsy; Tremor -- Periodicals; Hyperkinesia -- Periodicals; 616.8
• DOI: 10.7916/D8NK4XVP
• Languages: English
• ISSNs: 2160-8288

Abstract

Background: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. Case Report: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD. Discussion: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.