N-acylation of amides through internal nucleophilic catalysis. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Yao, Meng; Chen, Xia; Lu, Yuling; Guan, Zhenhua; Luo, Zengwei; Zhang, Yonghui
• Is Part Of: Journal of chemical research. Volume 45:Issue 1/2(2021)
• Page Start: 141
• Page End: 146
• Publication Date: 2021-01
• Subjects: imides -- internal nucleophilic catalysis -- Mumm rearrangement -- N, N-diisopropylethylamine -- pyridine; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.1177/1747519820925755
• Languages: English
• ISSNs: 1747-5198

Abstract

An efficient method for N -acylation of amides is described using a pyridine ring as the internal nucleophilic catalyst to give imides in moderate to excellent yields. The methodology provides a facile, air insensitive, and environmentally friendly route to form diversified imide scaffolds, which exist widely in natural products and biologically active materials.