Comparison of Urinary Alzheimer-Associated Neural Thread Protein (AD7c-NTP) Levels Between Patients With Amnestic and Nonamnestic Mild Cognitive Impairment. (20th January 2020)

• Record Type: Journal Article
• Authors: Ku, Bon D.; Kim, Hyeyun; Kim, Yong Kyun; Ryu, Han Uk
• Is Part Of: American journal of Alzheimer's disease & other dementias. Volume 35(2020)
• Publication Date: 2020-01-20
• Subjects: biomarker -- urine -- Alzheimer-associated neural thread protein (AD7c-NTP) -- mild cognitive impairment -- amnestic mild cognitive impairment -- nonamnestic mild cognitive impairment; Alzheimer's disease -- Periodicals; Dementia -- Periodicals; Alzheimer's disease -- Patients -- Care -- United States -- Periodicals; 616.83
• DOI: 10.1177/1533317519880369
• Languages: English
• ISSNs: 1533-3175

Abstract

Urinary Alzheimer-associated neural thread protein (AD7c-NTP) is a potential biomarker of Alzheimer disease (AD) or mild cognitive impairment (MCI). It is still unclear whether the urinary levels of AD7c-NTP are different between patients with amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The present study aimed to explore the differences in urinary levels of AD7c-NTP between patients with aMCI and naMCI. Forty-six patients with MCI were divided into aMCI group (n = 23) and naMCI group (n = 23). The mean level of urinary AD7c-NTP in the aMCI group (32.75 ± 10.0 µg/mL) was significantly higher than that in the naMCI group (25.34 ± 9.0 µg/mL; P = .011). As far as we know, the present study is the first to show that individuals with aMCI have higher levels of urinary AD7c-NTP than those with naMCI, suggesting that urinary AD7c-NTP may be a potential biomarker to help identify patients with aMCI and naMCI.