Perspective on Adversity in Toxicology Evaluations. (February 2021)

• Record Type: Journal Article
• Authors: Engelhardt, Jeffery A.; Dorato, Michael A.
• Other Names: Colman Karyn guest-editor.; Hall Anthony Peter guest-editor.; Vahle John guest-editor.
• Is Part Of: Toxicologic pathology. Volume 49:Number 2(2021)
• Page Start: 408
• Page End: 410
• Publication Date: 2021-02
• Subjects: adversity -- drug development -- preclinical safety-assessment/risk management -- safety assessment; Pathology -- Periodicals; Toxicology -- Periodicals; Pathology; Toxicology; 615.9
• DOI: 10.1177/0192623320941791
• Languages: English
• ISSNs: 0192-6233

Abstract

Determining adversity of effects in toxicology studies continues to pose a dilemma to practicing toxicologists and pathologists. How this determination is made may follow either a focused or broad approach to assessing the study data. The choice of which approach is best is dependent on a variety of factors. Therefore, we present a philosophical perspective on the determination of adversity across toxicology studies that may be applied in inhalation studies and those conducted by other routes of exposure.