Human Papillomavirus–Associated Anogenital Pathology in Females With HPV-Positive Oropharyngeal Squamous Cell Carcinoma. (February 2021)

• Record Type: Journal Article
• Authors: Larish, Alyssa; Yin, Linda; Glaser, Gretchen; Moore, Eric; Bakkum-Gamez, Jamie; Routman, David; Ma, Daniel; Price, Daniel; Janus, Jeffrey; Price, Katharine; Chintakuntlawar, Ashish; Neben-Wittich, Michelle; Foote, Robert; Van Abel, Kathryn
• Is Part Of: Otolaryngology--head and neck surgery. Volume 164:Number 2(2021)
• Page Start: 369
• Page End: 374
• Publication Date: 2021-02
• Subjects: oropharyngeal carcinoma -- anogenital carcinoma and disease -- human papillomavirus; Head -- Surgery -- Periodicals; Neck -- Surgery -- Periodicals; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0194599820941499
• Languages: English
• ISSNs: 0194-5998

Abstract

We sought to determine the incidence and location of human papillomavirus (HPV)–associated anogenital disease in women with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) via a retrospective cohort study with prospective contact to update history at Mayo Clinic in Rochester, Minnesota. Females undergoing treatment for nonmetastatic HPV-positive OPSCC from 2011 to 2019 were identified. Clinical history and outcomes were abstracted from medical records. Patients without documented anogenital history were contacted, consented, and administered a survey, and external records were requested and reviewed. Seventeen of 46 patients (37.0%) had a history of anogenital HPV-associated disease, and 16 of 17 (94.1%) required procedures to diagnose or treat HPV lesions. The cervix was the most common site (16/17, 94.1%). Procedures included colposcopy (n = 6), cervical excision (n = 3), cryotherapy (n = 4), and hysterectomy (n = 3). One case of fatal cervical carcinoma was noted, diagnosed 1 year following OPSCC. Three of 17 (17.6%) had HPV-related vulvovaginal disease, and 1 of 17 had anal disease. Patients with a history of HPV-positive OPSCC may be at elevated risk for HPV-associated anogenital disease.