A cross‐national study of depression in preclinical dementia: A COSMIC collaboration study. Issue 11 (3rd September 2020)

• Record Type: Journal Article
• Authors: Carles, Sophie; Carrière, Isabelle; Reppermund, Simone; Davin, Annalisa; Guaita, Antonio; Vaccaro, Roberta; Ganguli, Mary; Jacobsen, Erin P.; Beer, Joanne C.; Riedel‐Heller, Steffi G.; Roehr, Susanne; Pabst, Alexander; Haan, Mary N.; Brodaty, Henry; Kochan, Nicole A.; Trollor, Julian N.; Kim, Ki Woong; Han, Ji Won; Suh, Seung Wan; Lobo, Antonio; la Camara, Concepción De; Lobo, Elena; Lipnicki, Darren M.; Sachdev, Perminder S.; Ancelin, Marie‐Laure; Ritchie, Karen
• Is Part Of: Alzheimer's & dementia. Volume 16:Issue 11(2020)
• Page Start: 1544
• Page End: 1552
• Publication Date: 2020-09-03
• Subjects: dementia -- depression -- incidence; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12149
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Depression commonly accompanies Alzheimer's disease, but the nature of this association remains uncertain. Methods: Longitudinal data from the COSMIC consortium were harmonized for eight population‐based cohorts from four continents. Incident dementia was diagnosed in 646 participants, with a median follow‐up time of 5.6 years to diagnosis. The association between years to dementia diagnosis and successive depressive states was assessed using a mixed effect logistic regression model. A generic inverse variance method was used to group study results, construct forest plots, and generate heterogeneity statistics. Results: A common trajectory was observed showing an increase in the incidence of depression as the time to dementia diagnosis decreased despite cross‐national variability in depression rates. Discussion: The results support the hypothesis that depression occurring in the preclinical phases of dementia is more likely to be attributable to dementia‐related brain changes than environment or reverse causality.