Efficient Synthesis of Phosphonamidates through One‐Pot Sequential Reactions of Phosphonites with Iodine and Amines. Issue 63 (2nd October 2020)

• Record Type: Journal Article
• Authors: Chen, Xunwei; Luo, Wenjun; Wang, Yanlin; Li, Zikang; Ma, Xiaorui; Peng, Ai‐Yun
• Is Part Of: Chemistry. Volume 26:Issue 63(2020)
• Page Start: 14474
• Page End: 14480
• Publication Date: 2020-10-02
• Subjects: Arbuzov reaction -- iodine -- phosphonamidates -- phosphonates -- phosphonites; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202002934
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A one‐pot sequential strategy to construct phosphonamidates has been developed by generating phosphonites in situ from arylmagnesium bromides and triethyl phosphite followed by treatment with iodine and amines. A variety of phosphonamidates were obtained with good to excellent yields at room temperature from easily available materials. Abstract : Phosphonamidates in one pot : An iodine‐mediated one‐pot sequential phosphonoamidation of phosphonites with amines is developed. A variety of phosphonamidates were obtained from easily available starting materials with good to excellent yields under mild conditions.