Habitual sleep disturbances and migraine: a Mendelian randomization study. Issue 12 (30th October 2020)

• Record Type: Journal Article
• Authors: Daghlas, Iyas; Vgontzas, Angeliki; Guo, Yanjun; Chasman, Daniel I.; Saxena, Richa
• Other Names: Gormley Padhraig investigator.; Anttila Verneri investigator.; Winsvold Bendik S. investigator.; Palta Priit investigator.; Esko Tonu investigator.; Pers Tune H. investigator.; Farh Kai‐How investigator.; Cuenca‐Leon Ester investigator.; Muona Mikko investigator.; Furlotte Nicholas A. investigator.; Kurth Tobias investigator.; Ingason Andres investigator.; McMahon George investigator.; Ligthart Lannie investigator.; Terwindt Gisela M. investigator.; Kallela Mikko investigator.; Freilinger Tobias M. investigator.; Ran Caroline investigator.; Gordon Scott G. investigator.; Stam Anine H. investigator.; Steinberg Stacy investigator.; Borck Guntram investigator.; Koiranen Markku investigator.; Quaye Lydia investigator.; Adams Hieab H. H. investigator.; Lehtimäki Terho investigator.; Sarin Antti‐Pekka investigator.; Wedenoja Juho investigator.; Hinds David A. investigator.; Buring Julie E. investigator.; Schürks Markus investigator.; Ridker Paul M. investigator.; Hrafnsdottir Maria Gudlaug investigator.; Stefansson Hreinn investigator.; Ring Susan M. investigator.; Hottenga Jouke‐Jan investigator.; Penninx Brenda W. J. H. investigator.; Färkkilä Markus investigator.; Artto Ville investigator.; Kaunisto Mari investigator.; Vepsäläinen Salli investigator.; Malik Rainer investigator.; Heath Andrew C. investigator.; Madden Pamela A. F. investigator.; Martin Nicholas G. investigator.; Montgomery Grant W. investigator.; Kurki Mitja I. investigator.; Kals Mart investigator.; Mägi Reedik investigator.; Pärn Kalle investigator.; Hämäläinen Eija investigator.; Huang Hailiang investigator.; Byrnes Andrea E. investigator.; Franke Lude investigator.; Huang Jie investigator.; Stergiakouli Evie investigator.; Lee Phil H. investigator.; Sandor Cynthia investigator.; Webber Caleb investigator.; Cader Zameel investigator.; Muller‐Myhsok Bertram investigator.; Schreiber Stefan investigator.; Meitinger Thomas investigator.; Eriksson Johan G. investigator.; Salomaa Veikko investigator.; Heikkilä Kauko investigator.; Loehrer Elizabeth investigator.; Uitterlinden Andre G. investigator.; Hofman Albert investigator.; van Duijn Cornelia M. investigator.; Cherkas Lynn investigator.; Pedersen Linda M. investigator.; Stubhaug Audun investigator.; Nielsen Christopher S. investigator.; Männikkö Minna investigator.; Mihailov Evelin investigator.; Milani Lili investigator.; Göbel Hartmut investigator.; Esserlind Ann‐Louise investigator.; Christensen Anne Francke investigator.; Hansen Thomas Folkmann investigator.; Werge Thomas investigator.; Kaprio Jaakko investigator.; Aromaa Arpo J. investigator.; Raitakari Olli investigator.; Ikram M. Arfan investigator.; Spector Tim investigator.; Järvelin Marjo‐Riitta investigator.; Metspalu Andres investigator.; Kubisch Christian investigator.; Strachan David P. investigator.; Ferrari Michel D. investigator.; Belin Andrea C. investigator.; Dichgans Martin investigator.; Wessman Maija investigator.; van den Maagdenberg Arn M. J. M. investigator.; Zwart John‐Anker investigator.; Boomsma Dorret I. investigator.; Smith George Davey investigator.; Stefansson Kari investigator.; Eriksson Nicholas investigator.; Daly Mark J. investigator.; Neale Benjamin M. investigator.; Olesen Jes investigator.; Chasman Daniel I. investigator.; Nyholt Dale R. investigator.; Palotie Aarno investigator.;
• Is Part Of: Annals of clinical and translational neurology. Volume 7:Issue 12(2020)
• Page Start: 2370
• Page End: 2380
• Publication Date: 2020-10-30
• Subjects: Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1002/acn3.51228
• Languages: English
• ISSNs: 2328-9503

Abstract

Abstract: Objective: Sleep disturbances are associated with increased risk of migraine, however the extent of shared underlying biology and the direction of causal relationships between these traits is unclear. Delineating causality between sleep patterns and migraine may offer new pathophysiologic insights and inform subsequent intervention studies. Here, we used genetic approaches to test for shared genetic influences between sleep patterns and migraine, and to test whether habitual sleep patterns may be causal risk factors for migraine and vice versa. Methods: To quantify genetic overlap, we performed genome‐wide genetic correlation analyses using genome‐wide association studies of nine sleep traits in the UK Biobank ( n ≥ 237, 627), and migraine from the International Headache Genetics Consortium (59, 674 cases and 316, 078 controls). We then tested for potential causal effects between sleep traits and migraine using bidirectional, two‐sample Mendelian randomization. Results: Seven sleep traits demonstrated genetic overlap with migraine, including insomnia symptoms (rg = 0.29, P < 10 −31 ) and difficulty awakening (rg = 0.11, P < 10 −4 ). Mendelian randomization analyses provided evidence for potential causal effects of difficulty awakening on risk of migraine (OR [95% CI] = 1.37 [1.12–1.68], P = 0.002), and nominal evidence that liability to insomnia symptoms increased the risk of migraine (1.09 [1.02–1.16], P = 0.02). In contrast, there was minimal evidence for an effect of migraine liability on sleep patterns or disturbances. Interpretation: These data support a shared genetic basis between several sleep traits and migraine, and support potential causal effects of difficulty awakening and insomnia symptoms on migraine risk. Treatment of sleep disturbances may therefore be a promising clinical intervention in the management of migraine.