The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients. (9th November 2020)

• Record Type: Journal Article
• Authors: Yonata, Ade; Ali, Zulkhair; Indrajaya, Taufik; Bahar, Erial; Effendi, Ian; Suhaimi, Novadian; Suprapti, Suprapti
• Other Names: Kershaw David B. Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2020(2020)
• Publication Date: 2020-11-09
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.1155/2020/8893653
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : Introduction . Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia. Methods . We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B -mode ultrasound imaging. Results . A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33– 283) pg/mL, while the median cIMT was 0.8 (0.6– 1.45) mm. A relationship between the serum activin A level and cIMT ( r = 0.449; p = 0.001 ) was observed. During multivariate analysis with linear regression, triglyceride p = 0.049, phosphate p = 0.005, and activin A p = 0.020 serum levels were factors associated with cIMT. Conclusion . In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.