Surface engineering of SPIONs: role of phosphonate ligand multivalency in tailoring their efficacy. (9th September 2016)

• Record Type: Journal Article
• Authors: Lam, Tina; Avti, Pramod K; Pouliot, Philippe; Tardif, Jean-Claude; Rhéaume, Éric; Lesage, Frederic; Kakkar, Ashok
• Is Part Of: Nanotechnology. Volume 27:Number 41(2016)
• Publication Date: 2016-09-09
• Subjects: super paramagnetic iron oxide nanoparticles -- nanoparticle functionalization -- magnetic resonace imaging -- cell viability; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/0957-4484/27/41/415602
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: We report the design of scaffolds containing mono-, bis-, and tris-phosphonate coordinating groups, and a polyethylene glycol chain, for stabilizing superparamagnetic iron oxide nanoparticles (SPIONs), using simple and versatile chemistry. We demonstrate that the number of anchoring phosphonate sites on the ligand influence the colloidal stability, magnetic and biological properties of SPIONs, and the latter do not solely depend on attaching moieties that can enhance their aqueous dispersion. These parameters can be tailored by the number of conjugation sites on the ligand, as evidenced from dynamic light scattering at various salt concentrations, magnetic relaxivities and cell viability studies.