Synergistic Effect of Diacylglycerol and Vitamin D in Ameliorating Dextran Sodium Sulfate‐Induced Colitis in Rats. Issue 6 (18th May 2020)

• Record Type: Journal Article
• Authors: Liu, Yanan; Wang, Baowei; Xu, Huixin; Ge, Wenhua; Xie, Yue; Zhang, Mingai; Kong, Min; Fan, Wenlei
• Is Part Of: Lipids. Volume 55:Issue 6(2020)
• Page Start: 585
• Page End: 598
• Publication Date: 2020-05-18
• Subjects: Amelioration -- Colitis -- Cytokine -- Diacylglycerol -- Intestinal microflora -- Vitamin D; Lipids -- Periodicals; Lipids -- Periodicals; Lipiden; Lipides -- Périodiques; 547.77
• DOI: 10.1002/lipd.12248
• Languages: English
• ISSNs: 0024-4201

Abstract

Abstract: Vitamin D (VD) has the function of antibacteria and protect intestinal mucosa. Diacylglycerol has the property of dissolving VD, anti‐bacterial, and antioxidant effects. The purpose of this study was to explore the potentially synergistic effects of diacylglycerol and VD in ameliorating dextran sodium sulfate‐induced colitis in rats. A 2 × 3 factorial design was used in this experiment, consisting of two levels of VD (2.5 and 5 μg/day) crossed with three levels of duck oil diacylglycerol (0.5, 1, and 2 mL/day). The experiment lasted for 2 weeks. Compared with the colitis group, the physiological indexes were altered in colitis rats treated with diacylglycerol and VD, the concentrations of the pro‐inflammatory indices were significantly reduced, the antioxidant enzyme activities were significantly increased, the diversity of caecal microflora was significantly increased. Besides, the expression of PPARγ was up‐regulated while the expression of NF‐κBp65 was downregulated. The changes of all those measures were toward those in the Healthy Control, and the mostly appropriate combination was 1 mL/day of diacylglycerol plus 2.5 μg/day VD.