Bacteria‐Derived Nanoparticles: Multifunctional Containers for Diagnostic and Therapeutic Applications. Issue 22 (18th September 2020)

• Record Type: Journal Article
• Authors: Liu, Lin; Wu, Jiahe; Gao, Jianqing; Lu, Xiaoyang
• Is Part Of: Advanced healthcare materials. Volume 9:Issue 22(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-09-18
• Subjects: bacteria -- biomaterials -- cargo delivery -- nanoparticles; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202000893
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: In recent decades, investigations on bacteria‐derived materials have progressed from being a proof of concept to a means for improving traditional biomaterials. Owing to their unique characteristics, such as gene manipulation, rapid proliferation, and specific targeting, bacteria‐derived materials have provided remarkable flexibility in applied biomedical functionalization. In this review, bacteria‐derived nanoparticles are focused on as a promising biomaterial, introducing several bacterial species with great potential and useful strategies for fabrication. Through well‐designed choices, bacteria‐derived nanoparticles can be exploited to obtain functional bacteria‐mimicking materials for a variety of applications, including cargo delivery, imaging, therapy, and immune modulation. Finally, the prospects and challenges of bacteria‐derived nanoparticles are discussed. Particularly, safety concerns regarding the use of bacteria and their immunogenicity remain major obstacles to the clinical application of bacteria‐derived nanoparticles and these concerns are immediate priorities for the research community. Abstract : Bacteria‐derived materials have provided remarkable flexibility in applied biomedical functionalization. Several bacteria‐derived materials are approved in clinical application, indicating their advantages and great potential. Here, bacteria‐derived nanoparticles are focused as a promising biomaterial, introducing several bacterial species with great potential and useful strategies for fabrication, with an emphasis on their potential for biomedical applications.