Technical feasibility of magnetic resonance fingerprinting on a 1.5T MRI-linac. (11th November 2020)

• Record Type: Journal Article
• Authors: Bruijnen, T; van der Heide, O; Intven, M P W; Mook, S; Lagendijk, J J W; van den Berg, C A T; Tijssen, R H N
• Is Part Of: Physics in medicine & biology. Volume 65:Number 22(2020:Nov.)
• Publication Date: 2020-11-11
• Subjects: radiotherapy -- magnetic resonance fingerprinting -- MRI-linac -- tumor response monitoring; Biophysics -- Periodicals; Medical physics -- Periodicals; 610.153
• DOI: 10.1088/1361-6560/abbb9d
• Languages: English
• ISSNs: 0031-9155

Abstract

Abstract: Hybrid MRI-linac (MRL ) systems enable daily multiparametric quantitative MRI to assess tumor response to radiotherapy. Magnetic resonance fingerprinting (MRF ) may provide time efficient means of rapid multiparametric quantitative MRI. The accuracy of MRF, however, relies on adequate control over system imperfections, such as eddy currents and B 1 +, which are different and not as well established on MRL systems compared to diagnostic systems. In this study we investigate the technical feasibility of gradient spoiled 2D MRF on a 1.5T MRL. We show with phantom experiments that the MRL generates reliable MRF signals that are temporally stable during the day and have good agreement with spin-echo reference measurements. Subsequent in-vivo MRF scans in healthy volunteers and a patient with a colorectal liver metastasis showed good image quality, where the quantitative values of selected organs corresponded with the values reported in literature. Therefore we conclude that gradient spoiled 2D MRF is feasible on a 1.5T MRL with similar performance as on a diagnostic system. The precision and accuracy of the parametric maps are sufficient for further investigation of the clinical utility of MRF for online quantitatively MRI-guided radiotherapy.