Towards real-time finite-strain anisotropic thermo-visco-elastodynamic analysis of soft tissues for thermal ablative therapy. (January 2021)

• Record Type: Journal Article
• Authors: Zhang, Jinao; Lay, Remi Jacob; Roberts, Stuart K.; Chauhan, Sunita
• Is Part Of: Computer methods and programs in biomedicine. Volume 198(2021)
• Publication Date: 2021-01
• Subjects: Thermal ablation -- Bioheat transfer -- Biomechanics -- Finite-strain thermo-visco-elastodynamics -- Surgical simulation; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2020.105789
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: Fully nonlinear modelling of the coupled bioheat transfer and biomechanics. Finite-strain anisotropic thermo-visco-elastodynamic analysis of soft tissues. Thermo-visco-hyperelastic total Lagrangian explicit dynamics finite element algorithm. High-speed computation by efficient solution procedures and GPU computation. Bioheat-based temperature prediction and biomechanics-based image registration for thermal ablation. Abstract: Background and objectives: Accurate and efficient prediction of soft tissue temperatures is essential to computer-assisted treatment systems for thermal ablation. It can be used to predict tissue temperatures and ablation volumes for personalised treatment planning and image-guided intervention. Numerically, it requires full nonlinear modelling of the coupled computational bioheat transfer and biomechanics, and efficient solution procedures; however, existing studies considered the bioheat analysis alone or the coupled linear analysis, without the fully coupled nonlinear analysis. Methods: We present a coupled thermo-visco-hyperelastic finite element algorithm, based on finite-strain thermoelasticity and total Lagrangian explicit dynamics. It considers the coupled nonlinear analysis of (i) bioheat transfer under soft tissue deformations and (ii) soft tissue deformations due to thermal expansion/shrinkage. The presented method accounts for anisotropic, finite-strain, temperature-dependent, thermal, and viscoelastic behaviours of soft tissues, and it is implemented using GPU acceleration for real-time computation. Results: The presented method can achieve thermo-visco-elastodynamic analysis of anisotropic soft tissues undergoing large deformations with high computational speeds in tetrahedral and hexahedral finite element meshes for surgical simulation of thermal ablation. We also demonstrate the translational benefits of the presented method for clinical applications using a simulation of thermal ablation in the liver. Conclusion: The key advantage of the presented method is that it enables full nonlinear modelling of the anisotropic, finite-strain, temperature-dependent, thermal, and viscoelastic behaviours of soft tissues, instead of linear elastic, linear viscoelastic, and thermal-only modelling in the existing methods. It also provides high computational speeds for computer-assisted treatment systems towards enabling the operator to simulate thermal ablation accurately and visualise tissue temperatures and ablation zones immediately.