Association of Prepregnancy BMI, Gestational Weight Gain, and Child Birth Weight with Metabolic Dysfunction in Children and Adolescents with Obesity. Issue 10 (October 2020)

• Record Type: Journal Article
• Authors: Pearson, Kelsey; Jordan, Kristine C.; Metos, Julie; Holubkov, Richard; Nanjee, M. Nazeem; Mihalopoulos, Nicole L.
• Is Part Of: Southern medical journal. Volume 113:Issue 10(2020)
• Publication Date: 2020-10
• Subjects: children -- gestational weight gain -- obesity -- physical activity -- sedentary behavior; Medicine -- Periodicals; 610.5
• DOI: 10.14423/SMJ.0000000000001161
• Languages: English
• ISSNs: 0038-4348

Abstract

Abstract: Objectives: Previous studies have reported that maternal prepregnancy body mass index (BMI), gestational weight gain (GWG), and child birth weight are positively associated with metabolic dysfunction (a broader term than metabolic syndrome) in children and adolescents. Physical activity habits may play a role in reducing these risk factors. The objectives of this study were to investigate the association of prepregnancy BMI, GWG, child birth weight, physical activity, and sedentary time with metabolic dysfunction in a cohort of children and adolescents with obesity. Methods: Participants (N = 117; 53% Hispanic) were children and adolescents, aged 8 to 17 years, with obesity. Fasting serum glucose, insulin, and a complete lipid profile were obtained. Body weight, height, waist circumference, and blood pressure were measured. A self-reported survey assessed prepregnancy BMI, GWG, child birth weight, physical activity, and sedentary time. The χ 2 test and the Mantel-Haenzel test statistic were used to examine the differences in proportions for the outcome of metabolic dysfunction. Results: In this sample, 76.9% of children and adolescents had metabolic dysfunction. Prepregnancy BMI and GWG were not associated with metabolic dysfunction. Child birth weight and sedentary behavior were positively correlated ( P = 0.033 and P = 0.015, respectively) with a diagnosis of metabolic dysfunction. Physical activity levels were not associated with metabolic dysfunction. Hispanic and non-Hispanic youth were similar for all risk factors. Conclusions: Contrary to previous studies, prepregnancy BMI and GWG were not correlated with metabolic dysfunction. These findings support the need for lifestyle interventions, particularly in reducing sedentary behaviors, in obese children and adolescents. Abstract : Excess gestational weight gain and poor maternal nutritional status are associated with negative birth outcomes, including large-for-gestational-age, excess adiposity, and adverse cardiometabolic outcomes. This article describes the relations between maternal prepregnancy body mass index, gestational weight gain, child birth weight, and physical activity habits on cardiometabolic risk factors in children and adolescents with obesity.