Quinones from endophytic fungus Fusarium sp. HJT-P-5 of Rhodiola angusta Nakai. (October 2020)

• Record Type: Journal Article
• Authors: Lu, Xuan; Li, Yanjun; Qin, Haihong; Tang, Chuan; Zhang, Yu; Tang, Xiaoyuan; Wei, Lei; Feng, Baomin
• Is Part Of: Phytochemistry letters. Volume 39(2020)
• Page Start: 162
• Page End: 167
• Publication Date: 2020-10
• Subjects: Fusarium sp. HJT-P-5 -- Rhodiola angusta Nakai -- Quinones; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.08.008
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Fourteen quinone compounds were isolated from Rhodiola fungus Fusarium. Compounds 1, 8, 9, and 14 are new compounds. The cytostatic activity against G2 、A549、Hela and HCT116 cells of compound 1, 6, 7, 8, 9, 10, 11, 12, 13 and 14 was also reported. The absolute configuration of the ten-position carbon of compound 9 was determined using the Mosher method. The absolute configuration of the four-position carbon of compound 14 was determined by ECD calculation. Abstract: Fourteen quinones were isolated from endophytic fungus Fusarium sp. HJT-P-5 of Rhodiola angusta Nakai. The structures were determined by the chemical and spectroscopic methods. Compounds 1, 8, 9, and 14 are new compounds. The compounds 1, 6, 7, 8, 9, 10, 11, 12, 13 and 14 were evaluated for cytostatic activity against human liver cancer cells HepG2, human lung cancer cells A549, cervical cancer cells Hela, and human colorectal cancer cells HCT116.