A cancer-associated, genome protective programme engaging PKCε. (December 2020)

• Record Type: Journal Article
• Authors: Parker, Peter J.; Lockwood, Nicola; Davis, Khalil; Kelly, Joanna R.; Soliman, Tanya N.; Pardo, Ainara Lopez; Marshall, Jacqueline J.T.; Redmond, Joanna M.; Vitale, Marco; Silvia Martini,
• Is Part Of: Advances in biological regulation. Volume 78(2020)
• Publication Date: 2020-12
• Subjects: PKCe -- Cell cycle -- Non-disjunction -- Aurora B; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2020.100759
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: Associated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great deal of observational data, but has for the most part not afforded clear mechanistic insights into the control mechanisms at play. Here, we review the roles of PKCε in protecting transformed cells from non-disjunction. In this particular cell cycle context, there is a growing understanding of the pathways involved, affording biomarker and interventional insights and opportunities.