APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis. (December 2020)

• Record Type: Journal Article
• Authors: Schrock, Morgan S.; Stromberg, Benjamin R.; Scarberry, Luke; Summers, Matthew K.
• Is Part Of: Seminars in cancer biology. Volume 67(2021)Part 2
• Page Start: 80
• Page End: 91
• Publication Date: 2020-12
• Subjects: APC/C Anaphase Promoting Complex/Cyclosome -- TPR Tetratricopeptide Repeat -- D-Box Destruction Box, degron -- KEN Box Lysine-Glutamic Acid-Asparagine containing degron -- C-Mad2 Closed Mad2 Conformation -- O-Mad2 Open Mad2 Conformation -- SAC Spindle Assembly Checkpoint -- MCC Mitotic Checkpoint Complex -- CSCs Cancer Stem-like Cells -- TICs Tumor Initiating Cells -- SPOP Speckle-type POZ protein, Cullin 3 substrate adaptor -- SCF Skp1-Cul1-F-box, Ubiquitin Ligase -- PD-L1 Programmed-Death Ligand 1 -- CIN Chromosomal Instability -- TAME Tosyl-l-Arginine Methyl Ester (APC/C inhibitor) -- IDO Indoleamine 2, 3-dioxegnase -- PROTACs Proteolysis Targeting Chimeras -- TCGA The Cancer Genome Atlas -- TMA Tissue Microarray; Anaphase promoting complex/ cyclosome -- Cdc20 -- Cdh1 -- Genome instability -- Cancer; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2020.03.001
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the role of APC/C coactivators, Cdh1 and Cdc20, in cancer initiation and development. We summarize the current state of knowledge regarding APC/C structure and function, as well as the distinct ways Cdh1 and Cdc20 are dysregulated in human cancer. We also discuss APC/C inhibitors, novel approaches for targeting the APC/C as a cancer therapy, and areas for future work.