Two new compounds from Carpesium abrotanoides. (December 2020)

• Record Type: Journal Article
• Authors: Qian, Qun-Gang; Gong, Li-Min; Yang, Shen-Hui; Zhao, Bi-Qing; Cai, Jia; Zhang, Zheng-Jie; Wang, Yue-Hu; Zhou, Xiao-Jiang
• Is Part Of: Phytochemistry letters. Volume 40(2020)
• Page Start: 5
• Page End: 9
• Publication Date: 2020-12
• Subjects: Sesquiterpene -- Methyl 8-[2(5H)-furanon-5-yl]octanoate -- Carpesium abrotanoides L. -- Cytotoxic activity -- Anti-inflammatory activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.08.012
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new compounds were isolated from herbal material of Carpesium abrotanoides L. The structures of 1 and 2 were elucidated by single-crystal X-ray diffraction analysis and ECD calculation. Compound 1 showed moderate cytotoxicity against tumor cells with IC50 values ranging from 11.46 to 23.68 μM. Abstract: Two new compounds, named carpabrotalactone C (1 ) and methyl 8-[2(5 H )-furanon-5-yl]octanoate (2 ), were isolated from the herbs of Carpesium abrotanoides L. The structures of these compounds were elucidated based on spectroscopic analysis, single crystal X-ray diffraction analysis and ECD calculation. Compound 1 exhibited potent cytotoxicity against the A549, SMMC-7721, MCF-7 and SW480 cell lines, with IC50 values from 11.46 to 23.68 μM. Meantime, compound 1 showed weak inhibitory eff ;ects on LPS-induced NO release in RAW 264.7 cell lines, with IC50 value of 63.23 ± 2.55 μM.