A heavy atom free semiconducting polymer with high singlet oxygen quantum yield for photodynamic and photothermal synergistic therapy. (1st January 2021)

• Record Type: Journal Article
• Authors: Zhang, Xujing; Zhang, Aolin; Feng, Jingfei; Yi, Jing; Peng, Long; Chen, Jianjiao; Ke, Zhen; Yang, Jie; Dai, Yansong; Zou, Dengfeng
• Is Part Of: Materials & design. Volume 197(2021)
• Publication Date: 2021-01-01
• Subjects: Heavy atom free -- Semiconducting polymer -- Lung cancer -- Phototheranostics; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2020.109263
• Languages: English
• ISSNs: 0264-1275

Abstract

Abstract: Semiconducting polymers have been widely used for phototheranostics due to their strong absorbance in near infrared region, high photostability, excellent photothermal conversion ability. In this paper, a heavy atom free tri-component semiconducting polymer PTVT has been designed and synthesized by a Stille coupling reaction. PTVT has a high singlet oxygen quantum yield ( 1 O2 QY) of 42.2% in DCM remains high 1 O2 generation ability for the DSPE-PEG coated PTVT nanoparticles (NPs) obtained by a nanoprecipitation approach. Owing to the PDT and PTT synergistic therapy (photothermal conversion efficiency ~52.6%), PTVT NPs show a low half maximum inhibitory concentration (IC50 ) of 5.9 μg/mL towards human lung cancer cells (A549) with laser irradiation. And simultaneously the dark toxicity of such NPs is almost negligible even at high concentrations. Furthermore, in vivo study demonstrates that the NPs are able to inhibit tumor proliferation with laser irradiation, compared with the control and dark group, suggesting the low dark toxicity and high phototoxicity of such NPs. The H&E stained pictures of the normal tissues indicate the biosafety of PTVT NPs in that no obvious damage of heart, liver, lung, kidney and spleen was observed. The results provide an approach to designing heavy atom free semiconducting polymers for phototheranostics. Graphical abstract: Scheme Illustration of synthesis and application of PTVT NPs for phototherapy Unlabelled Image Highlights: Heavy atom free PTVT was prepared. PTVT nanoparticles (NPs) were prepared by nanoprecipitation with DSPE-PEG. PTVT NPs can inhibit cell proliferation both in vitro and in vivo .