Recent advances in ultrasound-triggered drug delivery through lipid-based nanomaterials. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Ahmadi, Amirhossein; Hosseini-Nami, Samira; Abed, Ziaeddin; Beik, Jaber; Aranda-Lara, Liliana; Samadian, Hadi; Morales-Avila, Enrique; Jaymand, Mehid; Shakeri-Zadeh, Ali
• Is Part Of: Drug discovery today. Volume 25:Issue 12(2020)
• Page Start: 2182
• Page End: 2200
• Publication Date: 2020-12
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2020.09.026
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: The side effects on healthy tissue are of drawbacks of cancer chemotherapy. Nanocarriers to transport of chemotherapeutics into the tumor are an ideal scenario. Hyperthermia acts like a trigger to release the drug from thermosensitive carriers. Lipid-based carriers following ultrasound activation exhibit an enhanced drug delivery. Ultrasound with lipid-based carriers may act a targeted chemotherapy as a "Trojan horse". Abstract : The high prescribed dose of anticancer drugs and their resulting adverse effects on healthy tissue are significant drawbacks to conventional chemotherapy (CTP). Ideally, drugs should have the lowest possible degree of interaction with healthy cells, which would diminish any adverse effects. Therefore, an ideal scenario to bring about improvements in CTP is the use of technological strategies to ensure the efficient, specific, and selective transport and/or release of drugs to the target site. One practical and feasible solution to promote the efficiency of conventional CTP is the use of ultrasound (US). In this review, we highlight the potential role of US in combination with lipid-based carriers to achieve a targeted CTP strategy in engineered smart drug delivery systems.