Immunotherapy in cervix cancer. (November 2020)

• Record Type: Journal Article
• Authors: Attademo, Laura; Tuninetti, Valentina; Pisano, Carmela; Cecere, Sabrina Chiara; Di Napoli, Marilena; Tambaro, Rosa; Valabrega, Giorgio; Musacchio, Lucia; Setola, Sergio Venanzio; Piccirillo, Patrizia; Califano, Daniela; Spina, Anna; Losito, Simona; Greggi, Stefano; Pignata, Sandro
• Is Part Of: Cancer treatment reviews. Volume 90(2020)
• Publication Date: 2020-11
• Subjects: Cervix cancer -- Immunotherapy -- Immune checkpoint inhibitor -- HPV; Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2020.102088
• Languages: English
• ISSNs: 0305-7372

Abstract

Highlights: Immunotherapy is a promising approach to advanced/ metastatic cervix cancer. More phase II and III trials are ongoing in locally advanced and metastatic cancer. We reviewed published data and discussed the therapeutic implications. Abstract: The treatment approach to cervix cancer has remained unchanged for several decades and new therapeutic strategies are now required to improve outcomes, as the prognosis is still poor. In the last years, a better understanding of HPV tumor–host immune system interactions and the development of new therapeutics targeting immune checkpoints generated interest in the use of immunotherapy in cervix cancer. Preliminary phase I–II trials demonstrated the efficacy, the duration of responses and the manageable safety of this approach. Currently, many phase II and III studies are ongoing in both locally advanced and metastatic cervical cancer, assessing immunotherapy as a single agent or in combination with chemotherapy and radiotherapy. We reviewed the published data and the therapeutic implications of the most promising novel immunotherapeutic agents under investigation in cervix cancer.