Efficient selective deacetylation of complex oligosaccharides using the neutral organotin catalyst [tBu2SnOH(Cl)]2. (December 2020)

• Record Type: Journal Article
• Authors: Ni, Minghong; Guerrini, Marco; Naggi, Annamaria; Petitou, Maurice
• Is Part Of: Carbohydrate research. Volume 498(2020)
• Publication Date: 2020-12
• Subjects: Selective deacetylation -- Tetra-tert-butyl-3-chloro-1-hydroxydistannoxane; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2020.108172
• Languages: English
• ISSNs: 0008-6215

Abstract

Abstract: Tetra- tert -butyl-3-chloro-1-hydroxydistannoxane has been found to selectively cleave with high efficiency primary acetates on complex oligosaccharides containing esterified l -iduronic acid and bearing an anomeric acetate. This tin based catalyst was found much more effective than magnesium methoxide to carry out selective deacetylation. Graphical abstract: Image 1 Highlights: Efficient selective deacetylation using organotin catalyst.