The impact of bisphenols on reproductive system and on offspring in pigs – A review 2011–2020. (January 2021)

• Record Type: Journal Article
• Authors: Bahelka, Ivan; Stupka, Roman; Čítek, Jaroslav; Šprysl, Michal
• Is Part Of: Chemosphere. Volume 263(2021)
• Publication Date: 2021-01
• Subjects: Bisphenol -- Pig -- Male -- Female -- Offspring -- Reproduction; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2020.128203
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: This study summarizes the knowledge about effects of bisphenol A (BPA) and its analogues on reproduction of pigs and some parameters of their offspring during period 2011–2020. Bisphenols are known as one of the most harmful environmental toxicants with endocrine-disrupting properties. One study in the reference period related to male reproductive system. Treatment with an antagonist of G-protein coupled estrogen receptor (GPER) – G15, and bisphenol A and its analogues, tetrabromobisphenol A (TBBPA) and tetrachromobisphenol A (TCBPA) diversely disrupted protein molecules controlling the biogenesis and function of microRNA in Leydig cells. Nine studies examined the effect of BPA, bisphenol S (BPS) or fluorene-9-bisphenol (BHPF) on female reproductive system. From the possible protective effect's point of view seems to be perspective the administration of melatonin in BPA-exposed oocytes. Finally, two studies were found to evaluate the maternal exposure to BPA on offspring's meat quality, muscle metabolism and oxidative stress. Administration of methyl donor improved antioxidant enzymes activity and reduced oxidative stress in piglets. Highlights: BPA and its analogues downregulated specific genes in boars BPA and analogues BPS, BPHF have an adverse effect on porcine oocytes. Methyl donor and melatonin supplementation reduced adverse impact of BPA on porcine oocytes. Melatonin administration had positive effect on BPA-exposed ovarian cells.