The impact of pyrolysis temperature on physicochemical properties and pulmonary toxicity of tobacco stem micro-biochar. (January 2021)

• Record Type: Journal Article
• Authors: Chen, Yi-Chun; Chen, Ku-Fan; Lin, Jun-Hong; Huang, Shih-Wei; Chen, Hung-Hsiang; Andrew Lin, Kun-Yi; Lin, Chia-Hua
• Is Part Of: Chemosphere. Volume 263(2021)
• Publication Date: 2021-01
• Subjects: Micro-biochars -- ROS -- Oxidative DNA damage -- Epithelial barrier -- Pyrolysis temperature; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2020.128349
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Biochars (BCs) are currently widely used, yet their impact on human health is mostly unknown. We generated micro-tobacco stem-pyrolysed BCs (mTBCs) at different pyrolysis temperatures and assessed pulmonary toxicity in normal human lung epithelial BEAS-2B cells. mTBCs generated at 350 °C (mTBC350) and 650 °C (mTBC650) were analysed and compared for physicochemical properties and adverse effects. Pyrolysis temperature had a significant influence on chemical composition, particle size, specific surface area and aromatic carbon structure. mTBC650 displayed a highly ordered aromatic carbon structure with smaller particle size, high surface area (20.09 m2/g) and high polycyclic aromatic hydrocarbon and metal content. This composition could promote reactive oxygen species accumulation accompanied by greater cytotoxicity, genotoxicity and epithelial barrier malfunction in cultured cells. Thus, the risk of pulmonary toxicity owing to micro-BCs (mBCs) is affected by pyrolysis temperature. Long-term exposure to mBCs produced at high temperatures may lead to or exacerbate pulmonary disease. Graphical abstract: Image 1 Highlights: Pyrolysis temperature had effects on physicochemical property of mBCs. The risk of pulmonary toxicity of mBCs is affected by pyrolysis temperature. mTBC650 could promote ROS generation accompanied by greater toxicity. . Exposure to mTBC650 may be associated with development of pulmonary disease.