An amorphous calcium phosphate for drug delivery: ATP provides a phosphorus source and microwave-assisted hydrothermal synthesis. (December 2020)

• Record Type: Journal Article
• Authors: Feng, Wenpo; Feng, Chenxi; Wang, Binbin; Jing, Aihua; Li, Guangda; Xia, Xichao; Liang, Gaofeng
• Is Part Of: Materials today communications. Volume 25(2020)
• Publication Date: 2020-12
• Subjects: Amorphous calcium phosphate (ACP) -- Microwave-assisted hydrothermal synthesis -- Drug delivery system; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2020.101455
• Languages: English
• ISSNs: 2352-4928

Abstract

Highlights: The calcium phosphate is a source of phosphorus provided by ATP, microwave assisted hydrothermal synthesis. It is amorphous and has essentially no cytotoxicity. It has moderate drug release abilities, and has strong drug-holding capacity. Abstract: An amorphous calcium phosphate (ACP) for drug delivery was synthesized by using microwave-assisted hydrothermal synthesis with ATP-Na2 provided a source of phosphorus. This ACP was characterized by X-ray power diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy(SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) specific surface area and hydrodynamic sizes. In vitro cytotoxicity evaluation was used by Mg-63 cells. Doxorubicins (Dox) were used as a model drug to evaluate the drug loading and release abilities. Results show the ACP, synthesized at 120 °Cand pH9 for 30 min, was consisted of aggregated porous microspheres, has essentially no cytotoxicity, moderate drug release abilities, and has strong drug-holding capacity. As an anticancer drug delivery, it has a high ability to damage and kill cancer cells. So, it is promising for applications in drug delivery.