Osteogenic Differentiation of Induced Pluripotent Stem Cells on Electrospun Nanofibers: A Review of Literature. (December 2020)

• Record Type: Journal Article
• Authors: Hashemi, Javad; Barati, Ghasem; Enderami, Seyed Ehsan; Safdari, Mohammadreza
• Is Part Of: Materials today communications. Volume 25(2020)
• Publication Date: 2020-12
• Subjects: iPSCs induced Pluripotent Stem Cells -- ECM Extracellular matrix -- ESCs Embryonic Stem Cells -- MSCs Mesenchymal Stem Cells -- PES Polyethersulfone -- ALP Alkaline Phosphatase -- TCPS Tissue Culture Polystyrene -- PVDF Polyvinylidene Fluoride -- PCL Polycaprolactone -- PVA Polyvinyl Alcohol -- PLLA Poly (L‐lactic acid) -- HAp/Col/CTS Hydroxyapatite/Collagen/Chitosan -- PLCL Poly(L-lactic acid-co-ε-caprolactone) -- SF Silk Fibroin -- PHBV Poly (3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) -- βGP β‐Glycerophosphate -- PEMF Pulsed Electromagnetic Field -- VN VitronectinPRP: Platelet‐Rich Plasma -- bFGF basic Fibroblast Growth Factor -- poly‐P Polyphosphates -- CT Cysteine knot -- CTGF Connective Tissue Growth Factor -- GO Graphene Oxide -- HA/HAp Hydroxyapatite -- μCT micro- Computed Tomography -- CM Conditioned Media -- IGFs Insulin‐Like Growth Factors -- VEGF Vascular Endothelial Growth Factor -- col Collagen -- miR microRNA -- CMC Carboxymethyl Chitosan -- PANi Polyaniline -- GEL Gelatin -- BGLAP Bone gamma-carboxyglutamate Gla protein -- BMP-2 Bone morphogenetic protein-2; induced pluripotent stem cells -- electrospun scaffold -- osteogenic differentiation -- scaffold modification; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2020.101561
• Languages: English
• ISSNs: 2352-4928

Abstract

Abstract: The use of induced pluripotent stem cells (iPSCs) has been widely exploited in bone regenerative medicine. The aim of tissue engineering is to provide an in vivo -like microenvironment for the clinical use of such stem cells. Electrospun nanofibrous scaffolds with high surface to volume ratio, interconnected pores, ability to control the parameters during fabrication, mimicking in vivo extracellular matrix (ECM), and enabling to retain growth factors could provide such an environment. Various studies have used electrospun scaffolds as a supportive matrix for osteogenic differentiation of iPSCs. Due to the unique nature of the bone, several attempts have been done to increase the mechano-chemical properties of electrospun scaffolds and accelerate the osteogenic differentiation of iPSCs cultured on these scaffolds. In this paper, the effects of electrospun scaffolds on osteogenic differentiation of iPSCs are reviewed.