Correspondence of optimal stimulation and beta power varies regionally in STN DBS for Parkinson disease. (September 2020) - Lu, Charles W.
Abstract: Introduction: Subthalamic nucleus deep brain stimulation (STN DBS) for Parkinson disease (PD) normalizes neuronal hypersynchrony in the beta frequency range (13–30 Hz). The spatial correspondence of maximal beta power to the site of optimal stimulation along the DBS lead trajectory has been debated. Methods: We determined the trajectory locations of the active contact, maximal beta power, and the dorsal border of the STN (DB-STN) in DBS patients. Beta power profiles were measured during intraoperative microelectrode recording (MER). Active contact locations were assigned during blinded, postoperative DBS programming. The DB-STN was identified both electrophysiologically during MER and anatomically on MRI. After grouping DBS trajectories into quadrants relative to the anatomic STN midpoint, we examined regional variations in the relative trajectory locations of the three entities. Results: STN DBS significantly improved motor performance for all 13 DBS patients, with active contacts at the DB-STN. Along trajectories passing posterior-medial to the STN midpoint, maximal beta power co-localized with active contacts at the DB-STN (difference Δ = 0.4 ± 1.6 mm, p = 0.57). By contrast, in posterior-lateral trajectories, maximal beta arose within the STN, ventral to active contacts (Δ = 1.9 ± 1.3 mm, p = 0.002). For trajectories anterior to the STN midpoint, maximal beta power co-localized with the DB-STN, while active contacts were ventral to peak beta power ( p = 0.05). Conclusion: Our findings indicate that co-localization of optimal stimulation and beta power varies by anatomical region in STN DBS for Parkinson disease. Highlights: Beta-oscillations (13–30 Hz) correlate with Parkinsonian motor symptoms. Subthalamic deep brain stimulation treats Parkinsonian motor symptoms. There is debate whether beta oscillations and optimal stimulation co-localize. Co-localization is absent in posterior-lateral and present in posterior-medial STN.