Co-infection of Middle Eastern respiratory syndrome coronavirus and pulmonary tuberculosis. (November 2020)

• Record Type: Journal Article
• Authors: Fatima, Bibi; Zaman, Gul
• Is Part Of: Chaos, solitons and fractals. Volume 140(2020)
• Publication Date: 2020-11
• Subjects: Epidemic model -- Middle eastern respiratory syndrome coronavirus (MERS-CoV) -- Reproductive number -- Stability analysis -- Bifurcation -- Sensitivity analysis -- Numerical simulation; Chaotic behavior in systems -- Periodicals; Solitons -- Periodicals; Fractals -- Periodicals; Chaotic behavior in systems; Fractals; Solitons; Periodicals; 003.7
• DOI: 10.1016/j.chaos.2020.110205
• Languages: English
• ISSNs: 0960-0779

Abstract

Highlights: We develop a mathematical model to represents the Middle East respiratory syndrome coronavirus and tuberculosis (TB) co-infection. We find basic reproductive number by using next generation method and discuss the stability of the model. We also study the bifurcation analysis of the model using the central manifold theory. Sensitivity of the basic reproductive number is performed to understand the most sensitive parameters. Finally, we show the feasibility of the analytical work, by numerical simulation. Abstract: Co-infection of Middle Eastern respiratory syndrome, coronavirus and tuberculosis, TB has a complex clinical entities that has estimated worldwide; mostly, in the Middle East. Clinical studies have shown that the propagation of disease is faster in (MERS-CoV) and TB co-infection compared to those of mono-infection. Clinical reports have shown that treatment of tuberculosis (TB) increase the risk of (MERS-CoV) reactivation. In this article, we propose an epidemic model to represents the Middle East respiratory syndrome coronavirus and tuberculosis (TB) co-infection. To do this, we first find the basic reproductive number and analyze the stability of the model. The stability conditions are obtained in term of the basic reproductive number. We also study the bifurcation analysis of the model, using the central manifold theory. Sensitivity of the basic reproductive number is performed to understand the most sensitive parameters. Finally, we show the feasibility of the analytical work, by numerical simulation.