Co-exposure of serum calcium, selenium and vanadium is nonlinearly associated with increased risk of type 2 diabetes mellitus in a Chinese population. (January 2021)

• Record Type: Journal Article
• Authors: Lv, Yingnan; Xie, Lianguang; Dong, Chunting; Yang, Rongqing; Long, Tianzhu; Yang, Haisheng; Chen, Lulin; Zhang, Lulu; Chen, Xiaolang; Luo, Xiaoyu; Huang, Sifang; Yang, Xiaobo; Lin, Rui; Zhang, Haiying
• Is Part Of: Chemosphere. Volume 263(2021)
• Publication Date: 2021-01
• Subjects: Metal co-exposure -- LASSO regression -- Restricted cubic splines regression -- Nonlinear relationship -- Type 2 diabetes mellitus; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2020.128021
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Background: Metals play an important role in type 2 diabetes mellitus (T2DM). This study aimed to explore the association of T2DM risk with single metal exposure and multi-metal co-exposure. Methods: A case-control study with 223 T2DM patients and 302 controls was conducted. Serum concentrations of 19 metals were determined by inductively coupled plasma mass spectrometry (ICP-MS). Those metals with greater effects were screened out and co-exposure effects of metals were assessed by least absolute shrinkage and selection operator (LASSO) regression. Results: Serum calcium (Ca), selenium (Se) and vanadium (V) were found with greater effects. Higher levels of Ca and Se were associated with increased T2DM risk (OR = 2.23, 95%CI: 1.38–3.62, P trend = 0.002; OR = 3.16, 95%CI: 1.82–5.50, P trend < 0.001), but higher V level was associated with decreased T2DM risk (OR = 0.58, 95%CI: 0.34–0.97, P trend < 0.001). Serum Ca and V concentrations were nonlinearly associated with T2DM risk ( P overall < 0.001, P nonliearity < 0.001); however, Se concentration was linearly associated with T2DM risk ( P overall < 0.001, P nonliearity = 0.389). High co-exposure score of serum Ca, Se and V was associated with increased T2DM risk (OR = 3.50, 95%CI: 2.08–5.89, P trend < 0.001) as a non-linear relationship ( P overall < 0.001, P nonliearity = 0.003). Conclusions: This study suggest that higher levels of serum Ca and Se were associated with increased T2DM risk, but higher serum V level was associated with decreased T2DM risk. Moreover, co-exposure of serum Ca, Se and V was nonlinearly associated with T2DM risk, and high co-exposure score was positively associated with T2DM risk. Highlights: Serum Ca level was nonlinearly associated with increased T2DM risk. Serum Se level was linearly associated with increased T2DM risk. Serum V level was nonlinearly associated with decreased T2DM risk. Co-exposure of Ca, Se and V was nonlinearly associated with increased T2DM risk.