Dendritic cells in Th2 immune responses and allergic sensitization. Issue 10 (10th September 2020)

• Record Type: Journal Article
• Authors: Lamiable, Olivier; Mayer, Johannes U; Munoz‐Erazo, Luis; Ronchese, Franca
• Is Part Of: Immunology and cell biology. Volume 98:Issue 10(2020)
• Page Start: 807
• Page End: 818
• Publication Date: 2020-09-10
• Subjects: Adaptive immunity -- allergy -- antigen presentation -- conventional dendritic cells -- T‐helper 2 cells; Immunology -- Periodicals; Cytology -- Periodicals; 616.079
• DOI: 10.1111/imcb.12387
• Languages: English
• ISSNs: 0818-9641

Abstract

Abstract: Allergic responses are characterized by the activation of a specific subset of effector CD4 + T cells, the T‐helper type 2 (Th2) cells, that respond to harmless environmental antigens causing inflammation and pathology. Th2 cells are also found in the context of parasite infections, where they can mediate parasite clearance and expulsion, and support tissue repair. The process that leads to the activation of Th2 cells in vivo is incompletely understood: while it has become clear that "conventional" dendritic cells are essential antigen‐presenting cells for the initiation of Th2 immune responses, the molecules that are expressed by dendritic cells exposed to allergens, and the mediators that are produced as a consequence and signal to naïve CD4 + T cells to promote their development into effector Th2, remain to be defined. Here we summarize recent developments in the identification of the dendritic cell subsets involved in Th2 responses, review potential mechanisms proposed to explain the generation of these immune responses, and discuss the direct and indirect signals that condition dendritic cells to drive the development of Th2 responses during allergen or parasite exposure. Abstract : The process that leads to the activation of T‐helper type 2 (Th2) cells in vivo is incompletely understood: while it has become clear that "conventional" dendritic cells are essential antigen‐presenting cells for the initiation of Th2 immune responses, the molecules that are expressed by dendritic cells exposed to allergens, and the mediators that are produced as a consequence and signal to naïve CD4 + T cells to promote their development into effector Th2, remain to be defined. Here we summarize recent developments in the identification of the dendritic cell subsets involved in Th2 responses, and the direct and indirect signals that condition dendritic cells to drive the development of Th2 responses.