Anticancer potential of docetaxel-loaded cobalt ferrite nanocarrier: an in vitro study on MCF-7 and MDA-MB-231 cell lines. (2nd January 2021)

• Record Type: Journal Article
• Authors: Panda, Jnanranjan; Satapathy, Bhabani Sankar; Mandal, Bidisha; Sen, Ramkrishna; Mukherjee, Biswajit; Sarkar, Ratan; Tudu, Bharati
• Is Part Of: Journal of microencapsulation. Volume 38:Number 1(2021)
• Page Start: 36
• Page End: 46
• Publication Date: 2021-01-02
• Subjects: Cobalt ferrite nanoparticles -- breast cancer -- docetaxel -- cytotoxicity -- biocompatibility; Microencapsulation -- Periodicals; Controlled release technology -- Periodicals; 615.19
• DOI: 10.1080/02652048.2020.1842529
• Languages: English
• ISSNs: 0265-2048

Abstract

Abstract: Aim: To develop a biocompatible cobalt ferrite (CF-NP) nanodrug formulation using oleic acid and poly (d, l -lactide- co -glycolic) acid (PLGA) for the delivery of docetaxel (DTX) specifically to breast cancer cells. Methods: The CF-NP were synthesised by hydrothermal method and conjugated with DTX in a PLGA matrix and were systematically characterised using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied. Results: The CF-NP showed good crystallinity with an average particle size of 21 nm and ferromagnetic nature. The DTX-loaded CF-NP (DCF-NP) showed 8.4% (w/w) drug loading with 81.8% loading efficiency with a sustained DTX release over time. An effective internalisation and anti-proliferative efficiency was observed in MCF-7 and MDA-MB-231 breast cancer cells and negligible haemolytic effect. Conclusion: The DCF-NP can have the potential for the effective delivery of DTX for breast cancer treatment.