Self-reporting heavy atom-free photodynamic therapy agents. Issue 46 (13th November 2020)

• Record Type: Journal Article
• Authors: Turkoglu, Gulsen; Kayadibi Koygun, Gozde; Yurt, Mediha Nur Zafer; Demirok, Naime; Erbas-Cakmak, Sundus
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 46(2020)
• Page Start: 9433
• Page End: 9437
• Publication Date: 2020-11-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01944e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Two novel near-IR absorbing, heavy atom-free BODIPY-based photosensitizers are reported to have efficient PDT action and self-reporting properties. Abstract : Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of 1 O2 generation without any significant change in photodynamic activity.