241 Bovine Respiratory Disease: Sex matters. (7th December 2018)
- Record Type:
- Journal Article
- Title:
- 241 Bovine Respiratory Disease: Sex matters. (7th December 2018)
- Main Title:
- 241 Bovine Respiratory Disease: Sex matters.
- Authors:
- Burdick Sanchez, N
Broadway, P
Carroll, J
Word, A
Littlejohn, B
Paulus Compart, D - Abstract:
- Abstract: To evaluate a potential sexual dimorphic innate immune response to respiratory disease, 8 steers and 7 heifers (BW=280 ± 4 kg) were subjected to a combined viral-bacterial respiratory disease challenge utilizing BHV-1 (intranasal; 1.0x10 8 PFU/mL/nostril) at -72h and Mannheimia haemolytica (MH ; intratracheal; 1.3x10 7 CFU/hd) at 0h. Following MH administration, serum was collected every h for 8h, and every 12h from 12 to 72h, and at 168h and was analyzed for cytokines. Whole blood was analyzed every other h from 0 to 8h, every 12h from 12 to 72h, and at 168h for hematology variables. Body temperature, measured from -72 to 69h via indwelling rectal or vaginal temperature monitoring devices, was greater in steers compared to heifers (40.06 vs. 39.60 ± 0.11 o C; P =0.008). Serum IL-4 was greater in steers than heifers (14.7 vs. 2.8 ± 2.7 pg/mL; P =0.007), while there was no difference ( P ≥0.10) in IL-6 or IFN-γ. There was a tendency ( P =0.09) for a treatment by time interaction for total white blood cells (WBC ), such that WBC were greater in steers than heifers at -72h, but were reduced in steers compared to heifers from 36 to 60h post-MH challenge. Neutrophils were elevated in steers compared to heifers from 0 to 4h, at 6h, and from 8 to 12h, but were reduced in steers compared to heifers at 168h ( P =0.02). Lymphocytes were reduced in steers compared to heifers at 12h and from 36 to 60h post-MH ( P PP=0.005). These data demonstrate distinct differences in theAbstract: To evaluate a potential sexual dimorphic innate immune response to respiratory disease, 8 steers and 7 heifers (BW=280 ± 4 kg) were subjected to a combined viral-bacterial respiratory disease challenge utilizing BHV-1 (intranasal; 1.0x10 8 PFU/mL/nostril) at -72h and Mannheimia haemolytica (MH ; intratracheal; 1.3x10 7 CFU/hd) at 0h. Following MH administration, serum was collected every h for 8h, and every 12h from 12 to 72h, and at 168h and was analyzed for cytokines. Whole blood was analyzed every other h from 0 to 8h, every 12h from 12 to 72h, and at 168h for hematology variables. Body temperature, measured from -72 to 69h via indwelling rectal or vaginal temperature monitoring devices, was greater in steers compared to heifers (40.06 vs. 39.60 ± 0.11 o C; P =0.008). Serum IL-4 was greater in steers than heifers (14.7 vs. 2.8 ± 2.7 pg/mL; P =0.007), while there was no difference ( P ≥0.10) in IL-6 or IFN-γ. There was a tendency ( P =0.09) for a treatment by time interaction for total white blood cells (WBC ), such that WBC were greater in steers than heifers at -72h, but were reduced in steers compared to heifers from 36 to 60h post-MH challenge. Neutrophils were elevated in steers compared to heifers from 0 to 4h, at 6h, and from 8 to 12h, but were reduced in steers compared to heifers at 168h ( P =0.02). Lymphocytes were reduced in steers compared to heifers at 12h and from 36 to 60h post-MH ( P PP=0.005). These data demonstrate distinct differences in the innate immune response following a BRD challenge such that steers produced an early response while the response in heifers was delayed. … (more)
- Is Part Of:
- Journal of animal science. Volume 96(2018)Supplement 3
- Journal:
- Journal of animal science
- Issue:
- Volume 96(2018)Supplement 3
- Issue Display:
- Volume 96, Issue 3 (2018)
- Year:
- 2018
- Volume:
- 96
- Issue:
- 3
- Issue Sort Value:
- 2018-0096-0003-0000
- Page Start:
- 23
- Page End:
- 24
- Publication Date:
- 2018-12-07
- Subjects:
- cattle -- respiratory disease -- sexual dimorphism
Livestock -- Periodicals
Livestock
Electronic journals
Periodicals
636.005 - Journal URLs:
- https://dl.sciencesocieties.org/publications/jas/index ↗
http://www.asas.org/jas/ ↗
https://academic.oup.com/jas ↗
http://www.oxfordjournals.org/ ↗ - DOI:
- 10.1093/jas/sky404.054 ↗
- Languages:
- English
- ISSNs:
- 0021-8812
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 14907.xml