Pattern of structural and functional brain abnormalities in asymptomatic granulin mutation carriers. (13th January 2014)

• Record Type: Journal Article
• Authors: Pievani, Michela; Paternicò, Donata; Benussi, Luisa; Binetti, Giuliano; Orlandini, Alberto; Cobelli, Milena; Magnaldi, Silvia; Ghidoni, Roberta; Frisoni, Giovanni B.
• Is Part Of: Alzheimer's & dementia. Volume 10(2014)Supplement 5
• Page Start: S354
• Page End: S363.e1
• Publication Date: 2014-01-13
• Subjects: FTLD -- Progranulin -- Magnetic resonance imaging -- Cortical thickness -- Diffusion tensor -- Resting‐state functional MRI; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2013.09.009
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: To investigate the patterns of brain atrophy, white matter (WM) tract changes, and functional connectivity (FC) abnormalities in asymptomatic granulin ( GRN ) mutation carriers. Methods: Ten cognitively normal subjects (five mutation carriers, GRN +; years to estimated disease onset: 12 ± 7; five mutation noncarriers, GRN −) underwent a clinical and imaging (structural, diffusion tensor, and resting‐state functional magnetic resonance imaging) assessment. Brain atrophy was measured with cortical thickness analysis, WM abnormalities with tract‐based spatial statistics, and FC with independent component analysis. Results: GRN + showed smaller cortical thickness than GRN − in the right orbitofrontal and precentral gyrus and left rostral middle frontal gyrus. WM tracts abnormalities were limited to increased axial diffusivity in the right cingulum, superior longitudinal fasciculus, and corticospinal tract. There were no differences in FC of resting‐state networks. Conclusion: Brain atrophy and WM tract abnormalities in frontal‐parietal circuits can be detected at least a decade before the estimated symptom onset in asymptomatic mutation carriers.