Electromagnetic evidence that benign epileptiform transients of sleep are traveling, rotating hippocampal spikes. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Wennberg, Richard; Tarazi, Apameh; Zumsteg, Dominik; Garcia Dominguez, Luis
• Is Part Of: Clinical neurophysiology. Volume 131:Issue 12(2020:Dec.)
• Page Start: 2915
• Page End: 2925
• Publication Date: 2020-12
• Subjects: BETS -- EEG -- Hippocampus -- Magnetic source imaging (MSI) -- MEG -- Small sharp spikes (SSS); Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2020.07.023
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Electromagnetic source imaging reveals BETS to be generated in the hippocampus. EEG/MEG detection of BETS dependent on longitudinally extended hippocampal source. Diphasic BETS waveform reflects back and forth propagation along hippocampal axis. Abstract: Objective: Benign epileptiform transients of sleep (BETS) have a unique voltage topography and a posteriorly propagating, inferiorly rotating diphasic EEG pattern. The source generators of BETS have not been definitively identified. We aimed to clarify the cerebral localization of BETS using MEG and electromagnetic source imaging (EMSI). Methods: We analyzed BETS recorded with simultaneous MEG and EEG in four patients with epilepsy. Magnetic source imaging (MSI) and EMSI using equivalent current, single moving and rotating dipole inverse models was performed on averaged BETS potentials. MEG beamforming was performed in one case with abundant BETS. Results: MSI and EMSI revealed hippocampal dipole source maxima in all cases, with current flow direction rotating from inferomedial to superomedial or superolateral between the first and second BETS peaks. Moving dipole analyses revealed spatiotemporal propagation along the anterior-posterior hippocampal axis and concomitant electromagnetic field rotation. Beamformer source reconstruction revealed an identical hippocampal localization. Conclusions: Converging evidence from different electromagnetic inverse modeling methods indicates that BETS are traveling, rotating hippocampal spikes, whose diphasic waveform is due to back and forth propagation along the anterior-posterior axis of the hippocampus. Significance: The hippocampal localization and longitudinal, rotating propagation pattern of BETS raises the possibility of a sleep-related functional role for these hippocampal spikes.