Association of cortical spreading depression and seizures in patients with medically intractable epilepsy. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Bastany, Zoya J.R.; Askari, Shahbaz; Dumont, Guy A.; Kellinghaus, Christoph; Kazemi, Alireza; Gorji, Ali
• Is Part Of: Clinical neurophysiology. Volume 131:Issue 12(2020:Dec.)
• Page Start: 2861
• Page End: 2874
• Publication Date: 2020-12
• Subjects: Refractory epilepsy -- Seizures -- Spreading depolarization -- DC recordings -- Brain; AC Alternating current -- ADIF Amplitude differential gain -- CSD cortical spreading depression -- CMRR Common Mode Rejection Ratio -- DC Direct current -- DRL driven Right Leg -- ECG electrocorticography -- ECoG Electrocardiogram -- EEG electroencephalogram -- EFP Epileptiform field potentials -- GABA γ-aminobutyric acid -- LTM long-term video-EEG monitoring -- MDC mobility and complexity -- PRED pattern related event distribution -- RSP relative spectral power -- SD standard deviation -- SE standard error -- STFT short-time Fourier transform; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2020.09.016
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: The occurrence of spreading depression and seizures were recorded in patients with epilepsy using a novel scalp AC/DC EEG approach. Complex interactions have been observed between spreading depression and seizures in patients with refractory epilepsy. Recordings of spreading depression may serve as diagnostic and prognostic monitoring tools in patients with intractable epilepsy. Abstract: Objective: Monitoring of the ultra-low frequency potentials, particularly cortical spreading depression (CSD), is excluded in epilepsy monitoring due to technical barriers imposed by the scalp ultra-low frequency electroencephalogram (EEG). As a result, clinical studies of CSD have been limited to invasive EEG. Therefore, the occurrence of CSD and its interaction with epileptiform field potentials (EFP) require investigation in epilepsy monitoring. Methods: Using a novel AC/DC-EEG approach, the occurrence of DC potentials in patients with intractable epilepsy presenting different symptoms of aura was investigated during long-term video-EEG monitoring. Results: Various forms of slow potentials, including simultaneous negative direct current (DC) potentials and prolonged EFP, propagated negative DC potentials, and non-propagated single negative DC potentials were recorded from the scalp of the epileptic patients. The propagated and single negative DC potentials preceded the prolonged EFP with a time lag and seizure appeared at the final shoulder of some instances of the propagated negative DC potentials. The slow potential deflections had a high amplitude and prolonged duration and propagated slowly through the brain. The high-frequency EEG was suppressed in the vicinity of the negative DC potential propagations. Conclusions: The study is the first to report the recording of the propagated and single negative DC potentials with EFP at the scalp of patients with intractable epilepsy. The negative DC potentials preceded the prolonged EFP and may trigger seizures. The propagated and single negative DC potentials may be considered as CSD. Significance: Recordings of CSD may serve as diagnostic and prognostic monitoring tools in epilepsy.