Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies. Issue 24 (15th December 2020)

• Record Type: Journal Article
• Authors: McNulty, James; Babu Dokuburra, Chanti; D'Aiuto, Leonardo; Demers, Matthew; McClain, Lora; Piazza, Paolo; Williamson, Kelly; Zheng, Wenxiao; Nimgaonkar, Vishwajit L.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 30:Issue 24(2020)
• Publication Date: 2020-12-15
• Subjects: Cyclopropanes -- Hydrazones -- Anti-viral -- HSV-1 -- Herpesvirus; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2020.127559
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5 ) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.